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The possible consequences of SARS-CoV-2 infection 

Long COVID has similarities to other post-viral syndromes, but there is still limited understanding about the nuances of this disease. In this bite-sized 15-minute podcast two experts discuss:

  • What is long COVID?
  • Patient sub-group susceptibility to long COVID
  • Treatment for long-term impairments from COVID-19 
  • Long COVID impacts and how to support different patient groups 
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      Loading      References:NICE, RCGP, and SIGN. COVID-19 rapid guideline: managing the long-term effects of COVID-19. Available at https://www.nice.org.uk/guidance/ng188/resources/covid19-rapid-guideline-managing-the-longterm-effects-of-covid19-pdf-51035515742 (accessed January 2023).World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. Available at https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1 (accessed January 2023).Davis HE, et al. EClinicalMedicine 2021;38:101019.Whitaker M, et al. Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people. medRxiv. Available at https://www.medrxiv.org/content/10.1101/2021.06.28.21259452v1 (accessed January 2023).Xie Y, et al. Nat Commun. 2021;12(1):6571.Staffolani S, et al. Infez Med 2022;30(1):22–29.Lopez-Leon S, et al. Sci Rep 2021;11(1):16144.ONS. Technical article: Updated estimates of the prevalence of post-acute symptoms among people with coronavirus (COVID-19) in the UK: 26 April 2020 to 1 August 2021. 2021. Available at https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/technicalarticleupdatedestimatesoftheprevalenceofpostacutesymptomsamongpeoplewithcoronaviruscovid19intheuk/26april2020to1august2021/pdf (accessed January 2023).KCE report 344Cs. Long COVID: pathophysiology – epidemiology and patient needs. 2021. Available at https://www.kce.fgov.be/sites/default/files/atoms/files/KCE_344C_Long_Covid_Short_report.pdf (accessed January 2023).Behnood SA, et al. J Infect 2022;84(2):158–170.Staffolani S, et al. Infez Med 2022;30(1):22–29.Trisha Greenhalgh T, et al. BMJ 2020;370:m3026.https://www.yalemedicine.org/conditions/long-covid-postacute-sequelae-of-sars-cov-2-infection-pasc (accessed January 2023)Coughlin SS. Public Health Rev. 2012;34(2).Oliver BG, et al. Eur Respir J. 2014;44(6):1666-81.Thompson EJ, et al. Risk factors for long COVID: analyses of 10 longitudinal studies and electronic health records in the UK. medRxiv. Available at https://www.medrxiv.org/content/10.1101/2021.06.24.21259277v1.full (accessed January 2023).Whitaker M, et al. Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people. medRxiv. Available at https://www.medrxiv.org/content/10.1101/2021.06.28.21259452v1 (accessed January 2023).Osmanov IM, et al. Eur Respir J 2022;59(2):2101341.Ortona E, et al. Cell Death Discov 2021;7(1):77.NICE, RCGP, and SIGN. COVID-19 rapid guideline: managing the long-term effects of COVID-19. Available at https://www.nice.org.uk/guidance/ng188/resources/covid19-rapid-guideline-managing-the-longterm-effects-of-covid19-pdf-51035515742 (accessed January 2023).Nature News. Can drugs reduce the risk of long COVID? What scientists know so far. 25 March 2022. Available at https://www.nature.com/articles/d41586-022-00823-y (accessed January 2023).Greenhalgh T, et al. Am Fam Physician 2020;102(12):716–717.NICE, RCGP, and SIGN. COVID-19 rapid guideline: managing the long-term effects of COVID-19. Available at https://www.nice.org.uk/guidance/ng188/resources/covid19-rapid-guideline-managing-the-longterm-effects-of-covid19-pdf-51035515742 (accessed January 2023).Buonsenso D, et al. J Paediatr Child Health 2022;58:201–202.Mayo Clinic. COVID-19 (coronavirus): Long-term effects. Available at https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-long-term-effects/art-20490351 (accessed January 2023).Xie Y, et al. Nature Med 2022;28:583–590.Cedars Sinai. Three big questions about long COVID. Available at https://www.cedars-sinai.org/discoveries/three-big-questions-about-long-covid.html (accessed January 2023).Ward H, et al. Lancet 2021;398(10316):2057–2059.Briggs A, et al. Nature 2021;593:502–505.Walker AJ, et al. Br J Gen Pract 2021;71:e806–814.      About Help restore protection with bivalent boosters

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